Product Details
Place of Origin: China
Brand Name: Hongbaiyi
Certification: COA, HPLC MR
Model Number: HBY-FOXO4-DRI
Payment & Shipping Terms
Minimum Order Quantity: 5 boxes
Price: negotiable
Packaging Details: 10mg/vial, 10vials/box
Delivery Time: 3-5 work days after your payment
Payment Terms: MoneyGram, Western Union, T/T
Supply Ability: 20,000 boxes/month
Item: |
Foxo4 Dri Peptide Buy |
CAS No.: |
910463-68-2 |
Molecular Formula: |
C228H388N86O64 |
Molecular Weight: |
5358.05 |
Storage Temp: |
FOXO4-D-Retro-Inverso Peptide,FOXO4-DRI Peptide,FOXO4-DRI Inhibitor FOXO4-p53 Disrupting Peptide,Senolytic FOXO4-DRI |
Specification: |
10mg/vials,10vails /box |
Peptide Type: |
Synthetic Peptide |
Item: |
Foxo4 Dri Peptide Buy |
CAS No.: |
910463-68-2 |
Molecular Formula: |
C228H388N86O64 |
Molecular Weight: |
5358.05 |
Storage Temp: |
FOXO4-D-Retro-Inverso Peptide,FOXO4-DRI Peptide,FOXO4-DRI Inhibitor FOXO4-p53 Disrupting Peptide,Senolytic FOXO4-DRI |
Specification: |
10mg/vials,10vails /box |
Peptide Type: |
Synthetic Peptide |
What is FOXO4-DRI?
FOXO4-DRI is a synthetic peptide designed to interfere with the interaction between the transcription factor FOXO4 and the protein p53. Cellular senescence is a state in which cells stop dividing and secrete inflammatory factors that can lead to aging and age-related diseases.
FOXO4-DRI is a promising therapeutic peptide that targets the interaction between FOXO4 and p53 in senescent cells, inducing apoptosis and potentially attenuating senescence-related decline and disease. Development and research of this drug are ongoing to translate these findings into clinical applications for improved health and longevity.
Interaction between FOXO4 and p53: FOXO4 is a transcription factor that plays a role in cell survival, oxidative stress response, and longevity. In senescent cells, FOXO4 interacts with p53, a key regulator of the cell cycle and apoptosis. This interaction sequesters p53 in the nucleus, preventing it from triggering apoptosis in these damaged cells.
| Product Name: | FOXO4-DRI |
| CAS No.: | 2460055-10-9 |
| Molecular Formula: | C228H388N86O64 |
| Molecular Weight: | 5358.05 |
| Sequence: | D-(Leu-Thr-Leu-Arg-Lys-Glu-Pro-Ala-Ser-Glu-Ile-Ala-Gln-Ser-Ile-Leu-Glu-Ala-Tyr-Ser-Gln-Asn-Gly-Trp-Ala-Asn-Arg-Arg-Ser-Gly-Gly-Lys-Arg-Pro-Pro-Pro-Arg-Arg-Arg-Gln-Arg-Arg-Lys-Lys-Arg-Gly) |
| Other names/Synonyms: |
FOXO4-D-Retro-Inverso peptide,FOXO4-DRI peptide, FOXO4-DRI inhibitor, FOXO4-p53 disrupting peptide, Senolytic FOXO4-DRI |
| Storage Temp: | Please seal and store at 8°C–20°C |
How does FOXO4-DRI work?
FOXO4-DRI is a synthetic peptide designed to interfere with the interaction between the transcription factor FOXO4 and the tumor suppressor protein p53, thereby inducing apoptosis in senescent cells. The following is a detailed explanation of how FOXO4-DRI works:
Mechanism of action of FOXO4-DRI:
FOXO4-DRI interferes with FOXO4-p53 interaction: FOXO4-DRI is a modified peptide that mimics a specific part of the FOXO4 protein. FOXO4-DRI is a modified peptide that mimics a specific part of the FOXO4 protein. It is designed to competitively inhibit the binding of endogenous FOXO4 to p53. By binding to p53 itself, FOXO4-DRI prevents FOXO4 from interacting with p53.
Release of p53: When FOXO4-DRI binds to p53, it releases p53 that has been sequestered by FOXO4, and the free p53 can then be transported to mitochondria, where it plays a role in initiating the apoptotic pathway.
Induction of Apoptosis: Once p53 is released and translocated to the mitochondria, it triggers apoptosis in senescent cells. This process involves the activation of pro-apoptotic proteins and the mitochondrial cell death pathway, which removes senescent cells.
What are the benefits of FOXO4-DRI?
FOXO4-DRI (FOXO4-D-Retro-Inverso) is a synthetic peptide that has attracted attention in the field of aging and senescence research for its potential therapeutic benefits. Below are the key benefits associated with FOXO4-DRI:
Reduction of Senescent Cells
Studies have shown that FOXO4-DRI can be specifically targeted to induce apoptosis in senescent cells without affecting healthy cells.
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