CAS 86168-78-7 (GHRH) Sermorelin 2mg Vial Peptide For Muscle Building

 CAS 86168-78-7 (GHRH) Sermorelin 2mg Vial Peptide For Muscle Building

Basic Information Form of  Sermorelin 

 
What is Sermorelin?
 
Sermorelin is a GHRH (growth hormone–releasing hormone) peptide analog. Its peptide sequence is comprised of 29 amino acids. This sequence is a portion of the endogenous human GHRH and is currently considered to be the shortest synthetic peptide that possesses the full array of functional GHRH activity. Due to this fact, sermorelin is considered to be a growth hormone secretagogue.
Sermorelin has been used during research to stimulate the secretion of growth hormone from the adenohypophysis (also called the anterior pituitary). The anterior pituitary secretes trophic hormones. Sermorelin has also been used in research stimulation tests to assess pituitary sufficiency in relation to the secretion of the growth hormone.
 
Growth hormone-releasing hormone
 
GHRH is a 44 amino-acids polypeptide that stimulates the secretion of growth hormone from the adenohypophysis. It is also called somatocrinin or somatoliberin. It is produced in the cell bodies of periventricular arcuate neurons and thereafter transported to the neurosecretory terminals of the neurons where they are released. The arcuate neurons do form part of the hypothalami-hypophyseal portal system. Their release from the neurosecretory terminals occurs in a pulsatile fashion and it thus follows that growth hormone (GH) release also occurs in a corresponding pulsatile fashion. GHRH binds to a secretin-type G-protein coupled serpentine receptor called the GHRH-receptor (GHRHR). Binding causes the receptor to activate both the cAMP (cyclic Adenosine Monophosphate)-a dependent pathway and the phospholipase C (PLC) pathway. The terminal downstream actions of the cAMP-dependent pathway do upregulate the transcription of both the GH and GHRHR genes thereby providing a positive feedback loop that amplifies the production of GH. The GH produced is thereafter packaged in secretory vesicles. The downstream actions of the PLC pathway result in both Na+-voltage-dependent and Ca2+-dependent fusion of the secretory vesicles with the plasma membrane thereby releasing GH into the bloodstream.
 
The actions of GH ensure optimal well-regulated post-natal growth. GH also promotes efficient energy metabolism. Studies have also shown that GHRH directly promotes slow-wave NREM (non-rapid eye movement) sleep, and thus GHRH insufficiency causes a reduction in the amount and intensity of slow-wave NREM sleep which results in either insomnia or dyssomnia (sleep disorders that cause sleep to lose its restorative capacity). Studies have also shown that GHRH inhibits the actions of somatostatin. Somatostatin is a polypeptide hormone that inhibits GH secretion from the adenohypophysis. Both GHRH and somatostatin are produced in the same neuron but they are released in alternation with each other thereby resulting in the pulsatile release of GH from the neuron.
 
Recent research has also shown that GHRH is also produced outside the hypothalamus by pancreatic cells, gastrointestinal tract epithelial cells, and in some neoplastic cells. Clinical studies have also shown that the actions of Sermorelin are similar to the GHRH actions. Thus, Sermorelin has been used to diagnose deficiencies in GH secretions.

 
How Sermorelin works?

All hormones act on specific target areas of the body. As sermorelin mimics the action of growth hormone-releasing hormone (GHRH), it also follows a specific course of action.
The growth hormone-releasing hormone receptors (GHRHr) is located in the anterior pituitary gland. Sermorelin binds to these receptors, triggering an increase in the production and secretion of growth hormone (GH) by somatic cells.
As feedback mechanisms maintain hormone levels, the increased serum concentration of growth hormone (GH) stimulates another endogenous hormone called somatostatin, also known as growth hormone inhibitory hormone (GHIH).
 
Growth hormone inhibitory hormone (GHIH) initiates a negative feedback mechanism to prevent somatic cells from secreting more growth hormone (GH) so that hormone levels do not become too high.
Thus, sermorelin ensures that the entire balance of hypothalamic-pituitary-somatopoietic protein coordination remains intact.
In addition to this, sermorelin improves the circadian rhythm associated with sleep by reducing the production of stress hormones. This further amplifies the release of growth hormone (GH).
 
Functions of Sermorelin
 
Increased fat burning
Better metabolic performance
Increased stamina, energy, and strength
Thicker and healthier skin
Reduces wrinkles and fine lines
Improved mood
Better quality of sleep
Improved sex drive
Improved mental clarity and cognition
Improved immune system and cardiovascular health
Faster recovery time

 
Product Image of Sermorelin