Ovagen 20mg | 99% Purity

Glu-Asp-Leu (EDL) 20mg Per Vial Ovagen Liver Protection Lyophilized Powder

Overview of Ovagen 20mg Peptide

Ovagen is a synthetic tripeptide bioregulator designed primarily for research into liver and gastrointestinal (GI) tract health. It is not approved for human therapeutic use and is supplied as a lyophilized powder in 20mg vials for laboratory purposes. Developed based on work by Dr. Vladimir Khavinson, it targets age-related changes in DNA expression to promote cellular repair and normalization of organ function.

It exhibits tissue-specific effects, crossing cell and nuclear membranes to interact with DNA and chromatin proteins via peptide transporters (e.g., PepT1/PepT2), which enhances its bioavailability compared to larger peptides.

How Does Ovagen Work?

Ovagen operates through epigenetic mechanisms: it enters cells via peptide transporters, translocates to the nucleus, and influences chromatin structure to modulate gene expression. This can upregulate genes for cellular repair and stress response while downregulating those linked to inflammation or fibrosis. In liver and GI models, it promotes tissue-specific effects like enhanced protein synthesis and reduced oxidative damage, without relying on traditional receptor binding.

Mechanism of Action

Ovagen works by decondensing age-associated DNA changes in liver fibroblasts and GI mucosal cells, increasing gene availability for transcription. This results in reduced cellular senescence, normalized protein synthesis, and enhanced enzyme production. It also inhibits oxidative stress, lipid peroxidation, and inflammatory signaling, while protecting against fibrosis and toxins. In preclinical models, it acts as an HIV-1 protease inhibitor at low concentrations (e.g., 50 μM), thereby preventing viral maturation without the development of rapid resistance.

Benefits and Research Findings

Research (primarily preclinical and from Eastern European studies) highlights Ovagen's potential in organ repair and anti-aging. Key benefits include:

• Liver Protection and Regeneration: Reduces long-term fibrosis, normalizes enzyme levels (e.g., ALT/AST), and promotes hepatocyte proliferation to prevent cirrhosis from toxins, alcohol, or medications.

• GI Tract Support: Strengthens mucosal barriers against antibiotics, chemotherapy, malnutrition, and environmental insults, aiding detoxification and barrier function.

• Anti-Aging Effects: Resets DNA to a youthful state in aging liver and gut cells, slowing functional decline and supporting mitochondrial health.

• Immune and Recovery Modulation: Balances inflammation, enhances redox balance, and speeds recovery from stress, with potential in postoperative care, diabetes prevention, and hormone regulation.

• Other Potential: Inhibits HIV replication; may improve nutrient handling and energy production for performance enhancement.

Studies show robust effects in older models, with well-tolerated profiles and no significant immunogenicity.

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Usage and Dosage

Ovagen is studied in oral capsules, injectables, or sublingual forms. Example protocols (not for human use):