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Shaanxi Hongbaiyi Biotech Co., Ltd.
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Intermediate Peptide Mots-C (human) for Osteoporosis CAS 1627580-64-6

Product Details

Place of Origin: China

Brand Name: Hongbaiyi

Certification: COA, HPLC MR

Model Number: HBY-Mots-C

Payment & Shipping Terms

Minimum Order Quantity: 1KG

Price: Negotiable

Packaging Details: 10mg/vial, 10vials/box

Delivery Time: 3-5 work days after your payment

Payment Terms: Western Union, T/T, MoneyGram, Western Union

Supply Ability: 4000kg/Month

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Specifications
Highlight:
NAME:
Peptide Intermediate Mots-C (human) For Osteoporosis CAS 1627580-64-6
APPEARANCE:
WHITE, POWDER
ASSAY:
99%
CAS:
1627580-64-6
Molecular Weight:
2174.6
Molecular Formula:
C101H152N28O22S2
Temperture:
2-8℃
SHELF LIFE:
2 YEARS
NAME:
Peptide Intermediate Mots-C (human) For Osteoporosis CAS 1627580-64-6
APPEARANCE:
WHITE, POWDER
ASSAY:
99%
CAS:
1627580-64-6
Molecular Weight:
2174.6
Molecular Formula:
C101H152N28O22S2
Temperture:
2-8℃
SHELF LIFE:
2 YEARS
Description
Intermediate Peptide Mots-C (human) for Osteoporosis CAS 1627580-64-6

What is Peptide Intermediate Mots-C (human) For Osteoporosis CAS 1627580-64-6?

 

Mitochondria are known to be functional organelles, but their role as a signaling unit is increasingly being appreciated. The identification of a short open reading frame (SORF) in the mitochondrial DNA (mtDNA) that encodes a signaling peptide, humanin, suggests the possible existence of additionalSORFS in the mtDNA. Here we report a SORF within the mitochondrial 12S RRNA encoding a 16-amino-acid peptide named MOTS-C (mitochondrial open reading frame of the 12S RRNA-C) that regulates insulin sensitivity and metabolic homeostasis. Its primary target organ appears to be the skeletal muscle, and its cellular actions inhibit the folate cycle and its tethered de novo purine biosynthesis, leading to AMPK activation. MOTS-C treatment in mice prevented age-dependent and high-fat-diet-induced insulin resistance, as well as diet-induced obesity.

 

These results suggest that mitochondria may actively regulate metabolic homeostasis at the cellular and organismal level via peptides encoded within their genome.

 

Product Name Peptide Intermediate Mots-C (human) For Osteoporosis CAS 1627580-64-6
Appearance White, powder
Specification 10mg/vial
Assay 99%min
Test HPLC
CAS 1627580-64-6
MF C101H152N28O22S2
Storage 2-8℃

 

Intermediate Peptide Mots-C (human) for Osteoporosis CAS 1627580-64-6 0

Intermediate Peptide Mots-C (human) for Osteoporosis CAS 1627580-64-6 1

 

Application:

 

MOTS-C in Osteoporosis

 

Osteoporosis is a multi-factor and age-related metabolic disease. Bone mesenchymal stem cells (BMSCS) are the progenitor cells of osteoblasts and adipocytes and play an essential role in the process of bone formation.

 

AMPK can stimulate the proliferation, differentiation and mineralization of osteoblasts, which exerts an important role in the cellular functions of osteoblasts. Osteoblasts are cells that make bone. Bone mass is maintained by a balance between the activity of osteoblasts that form bone and other cells called osteoclasts that break it down.

 

Studies show that BMSC’s treated with MOTS-C upregulated expression levels of ALP, Bglap, and Runx2. This resulted in the formation of mineralized nodules, indicating the osteogenic capacity of BMSC’s regulated by MOTS-C. In simple nonscientific terms,

MOTS-C promotes cell differentiation of BMSCs to osteoblasts = bone formation.

 

Function:

 

Promotes fatty acid metabolism in the liver

Promotes metabolic flexibility and homeostasis

Helps regulate mitochondrial energy

Protects against age and diet dependent insulin resistance and obesity

Helps with weight loss

Promotes resistance to metabolic stress

Improves exercise capacity

Helps prevent osteoporosis

Improves glucose regulation

Promotes cell differentiation to form osteoblasts

 

Package and shipping of Peptide Intermediate Mots-C (human) For Osteoporosis CAS 1627580-64-6

 

    Package

Intermediate Peptide Mots-C (human) for Osteoporosis CAS 1627580-64-6 2

  Shipping 

 

    With 3-5 work days after your payment.

 

FAQ of Peptide Intermediate Mots-C (human) For Osteoporosis CAS 1627580-64-6

 

Q1: Do you Accept Sample Order?

A: Yes. The smallest order we accept is one box.

 

Q2: Do you accept VISA business credit card?

A: Yes. VISA business credit card is in our payment .

 

Q3: Is there any discount?
A: Yes, if you want to purchase larger quantity, we can offer better price for you.

 

Q4: How long does it take to me if I order?

A: About 3-5 days upon recepient of payment.

 

Q5: What kind of transportation do you have?

A: We have many ways of transportations, eg: Air, Sea, Special Lines,TNT, FEDEX, EMS, ect.

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